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Agnieszka Radwanska reacts during her match against Ashleigh Barty at the Wuhan Open on Wednesday. Photo: VCG

Agnieszka Radwanska warned Wednesday the world's top female players are exhausted after a long season and said it was little surprise most of the seeds have tumbled out at the Wuhan Open.

Radwanska, the ninth seed, crashed out of the hot and sticky tournament at the hands of Australia's Ashleigh Barty after struggling to overcome a virus that had forced her out of the Pan Pacific Open in Tokyo.

She joined the exodus of tournament favorites including Romanian Simona Halep, the second seed, and Dane Caroline Wozniacki, the fourth seed, during the early rounds in Wuhan.

"Some of the girls are tired. ­Obviously it's the end of the season," 28-year-old Radwanska told AFP on Wednesday ­after going down 4-6, 6-0, 6-4. "Nobody's a machine here; you can just be exhausted after a couple of months playing tennis. These things happen."

Wuhan falls at a busy time of year in the women's schedule, sandwiched between the Pan Pacific Open in Tokyo and the China Open in Beijing. They have weeks still to play before the final tournament of the season, the Fed Cup, in early November.

Caroline Wozniacki, world No.6, was on Tuesday upset 7-5,6-3 in the second round by Maria Sakkari, ranked 80th in the world, just days after jetting in from Tokyo, where she captured her first title of the year. She had previously fought her way through six finals, losing in each one.

Speaking before her first match in Wuhan, Wozniacki said she found the tight schedule mentally challenging.

"I'm feeling OK [physically]. It's more mentally ... getting yourself up in the morning and having to be competitive and not just being able to take a chilled day," she said.

Meanwhile Halep, ranked second in the world, appeared to have the opposite problem after playing her first match since crashing out of the US Open second round a month ago.

"Maybe it was a mistake that I didn't play, but I needed rest after the US season," she told journalists after suffering a shock 6-2, 6-1 defeat to Russia's Daria Kasatkina. "It's tough to come back and to play matches."

The three stars followed fellow seeds Johanna Konta, Sloane Stephens, Madison Keys and Petra Kvitova among others out the exit.

Fabrice Chouquet, co-tournament ­director in Wuhan, said, "It's the end of the season, probably where certain ­players tend to be tired, but we've always had great winners. Petra [Kvitova] twice, Venus [Williams] once, and that's just the nature of tennis."

Also on Wednesday, top seed Garbine Muguruza fended off the challenge of qualifier Magda Linette for a hard-fought 6-2, 1-6, 6-4 win in two hours and three minutes to book her place in the quarterfinals.

In the quarterfinals, Muguruza will face a fellow Slam holder who came through a three-set tussle in Jelena ­Ostapenko. Remarkably, it will be the very first meeting in 2017 between any of this year's four Slam champions.