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Anticipating that Hurricane Irma will "devastate" part of the US, officials were preparing a massive response to the storm, the head of the US Federal Emergency Management Agency (FEMA) said Friday.

With Irma set to hit Florida as early as Saturday night, parts of Florida was expected to lose electricity for days, if not longer, and more than 100,000 people may need shelter, FEMA Administrator Brock Long warned.

"Hurricane Irma continues to be a threat that is going to devastate the US in either Florida or some of the southeastern states," Long said.

Irma was a Category-5 hurricane, the most dangerous measure by the National Hurricane Center, before being downgraded to Category-4 early Friday after pummeling islands in the Caribbean.

The US has experienced only three Category-5 storms since 1851 and Irma is far larger than the last one to hit the US in 1992, Hurricane Andrew, according to Long.

He warned people not to ignore evacuation orders.

"They need to get out and listen and heed the warnings," Long said.

Officials have thousands of personnel ready to respond and millions of meals and liters of water in place nearby, Long said.

The National Weather Service said that Friday was the last day to evacuate before winds would start to reach unsafe speeds in Florida.

Airlines added extra flights from Florida on Thursday before announcing plans to halt service from some southern Florida airports starting Friday.

US Health and Human Services Secretary Tom Price called Irma a "remarkably dangerous storm and the window to get yourself in the right spot ... is closing rapidly."

Price said the main hospital in St. Thomas in the US Virgin Islands was closed after being damaged by Irma, and critically ill patients were being evacuated to Puerto Rico or other islands.

On Thursday, the US Senate voted 80-17 to approve a measure to more than double funding to $15.25 billion to FEMA and for local block grants to handle natural disasters.